With advancements in automation, compute power, and visual technology, the scope and complexity of datasets used in cryo-EM have grown substantially. They just request that if RELION is useful in your work, that you cite their papers. This means that anyone (including commercial users) can download, use and modify RELION without having to pay anything. The development of RELION is supported through long-term funding by the UK Medical Research Council, and is distributed under a GPLv2 license. Developed by Scheres Lab at the MRC Laboratory of Molecular Biology, this stand-alone computer program uses a Bayesian approach to refine macromolecular structures by single-particle analysis of electron cryo-microscopy data. RELION (REgularised LIkelihood OptimisatioN), or Relion, has revolutionized the cryo–EM field since 2012.
In this blog post we benchmark the RTX A4000 performance using Relion Cryo-EM, comparing GPU runtime to Total Runtime performance. As a value-added supplier of scientific workstations and servers, Exxact regularly provides reference benchmarks in various GPU configurations to guide Cryogenic electron microscopy (cryo-EM) scientists looking to procure systems optimized for their research.
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